Multi-component extracellular matrices based on peptide self-assembly
نویسندگان
چکیده
منابع مشابه
MaP peptides: programming the self-assembly of peptide-based mesoscopic matrices.
We describe an approach that utilizes nonlinear peptides to direct the assembly of previously reported Self-Assembling Fibers (SAFs). The SAF system comprises two complementary linear peptides, SAF-p1 and SAF-p2a, which combine to form exclusively linear, nonbranched fibers. The Matrix-Programming (MaP) peptides described herein are based on these peptides: they comprise two or three half-pepti...
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[5]Pseudorotaxanes can be obtained by self-sorting using heteroditopic guests and various cucurbituril homologues as hosts. The assembly and chemically induced disassembly of the pseudorotaxanes can be monitored by measuring the fluorescence of the anthracene guest in solution. Mass spectral evidence for the supramolecular assemblies is obtained in the gas phase. The disassembly in the gas phas...
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Amphiphilic peptide (AP), which behaves in some respects like amphiphilic surfactants, is a class of molecule that consists of a hydrophilic peptide segment and a hydrophobic domain. In water, these molecules generally self-assemble into rods with a hydrophobic core. The peptide segments outside the hydrophobic core always prefer a β-sheet conformation. As introduced in the latest reviews [23,2...
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Amphiphilic peptides suspended in aqueous solution display a rich set of aggregation behavior. Molecular-level studies of relatively simple amphiphilic molecules under controlled conditions are an essential step toward a better understanding of self-assembly phenomena of naturally occurring peptides/proteins. Here, we study the influence of molecular architecture and interactions on the self-as...
متن کاملAtomic structures of peptide self-assembly mimics.
Although the beta-rich self-assemblies are a major structural class for polypeptides and the focus of intense research, little is known about their atomic structures and dynamics due to their insoluble and noncrystalline nature. We developed a protein engineering strategy that captures a self-assembly segment in a water-soluble molecule. A predefined number of self-assembling peptide units are ...
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ژورنال
عنوان ژورنال: Chemical Society Reviews
سال: 2010
ISSN: 0306-0012,1460-4744
DOI: 10.1039/b914337h